BUFFER SOLUTIONS HAVING SELECTIVE BACTERICIDAL ACTIVITY AGAINST GRAM NEGATIVE BACTERIA AND METHODS OF USING SAME

摘要

A buffer solution with an effective amount of treprostinil and/or treprostinil sodium for use in the treatment of pulmonary arterial hypertension in a human subject in need thereof is provided. The buffer solution is obtainable by a process comprising diluting a starting solution of treprostinil and/or treprostinil sodium with a buffer comprising glycine and having a pH of greater than 10.