发明名称 |
Recombinant adenylate cyclase toxin of bordetella induces T cell responses against tumoral antigens |
摘要 |
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA-A*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyA-E5-Tyr and CyaA-E5-GnT-V. |
申请公布号 |
EP2193804(A3) |
申请公布日期 |
2010.06.30 |
申请号 |
EP20090177668 |
申请日期 |
2004.11.19 |
申请人 |
INSTITUT PASTEUR;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);LUDWIG INSTITUTE FOR CANCER RESEARCH;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
DADAGLIO, GILLES;LECLERC, CLAUDE;LADANT, DANIEL;VAN DEN EYNDE, BENOIT;MOREL, SANDRA;BAUCHE, CECILE |
分类号 |
A61K39/385;A61K38/16;A61K39/00;A61K39/02;A61K39/39;A61K47/48;A61K48/00;A61P35/00;C07H21/04;C12N1/21;C12N9/02;C12N9/88;C12N15/62;C12N15/63;C12P21/04 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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