发明名称 |
SMALL MOLECULE INHIBITION OF INTRACELLULAR TRANSPORT |
摘要 |
The present disclosure characterizes the activity of Golgicide A (GCA), as a potent, specific and reversible small molecule inhibitor of Golgi BFA resistance factor 1 (GBF1) function. A mutant GBF1 gene that is resistant to GCA is also described. Methods of using GCA and the GCA-resistant GBF1 gene are described including methods for modulating GBF1 activity for research and therapeutic purposes. Also described are compositions incorporating a GCA-resistant GBF1.
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申请公布号 |
US2010159468(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
US20090645094 |
申请日期 |
2009.12.22 |
申请人 |
THE WASHINGTON UNIVERSITY |
发明人 |
HASLAM DAVID B. |
分类号 |
C12Q1/68;C07H21/00;C12N5/07;C12N5/071;C12N15/74 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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