| 发明名称 |
MODULATION OF SGLT2 EXPRESSION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a therapeutic compound targeting specific SGLT species. <P>SOLUTION: There is provided an oligomer compound having a nucleic acid base length of 8-80 and targeting a nucleic acid molecule encoding SGLT2, wherein the compound is complementary at least 70% to the nucleic acid encoding SGLT2 and inhibits at least 10% expression of SGLT2 mRNA. <P>COPYRIGHT: (C)2010,JPO&INPIT |
| 申请公布号 |
JP2010136725(A) |
申请公布日期 |
2010.06.24 |
| 申请号 |
JP20100017256 |
申请日期 |
2010.01.28 |
| 申请人 |
ISIS PHARMACEUTICALS INC |
发明人 |
FREIER SUSAN M;WANCEWICZ EDWARD;MONIA BRETT P;SIWKOWSKI ANDREW M;WATTS LYNNETTA;LEEDOM THOMAS A |
| 分类号 |
C12N15/113;A61K31/70;A61K31/711;A61K31/713;A61K48/00;A61P3/04;A61P3/06;A61P3/10;A61P9/00;A61P9/12;C07H;C07H21/02;C07H21/04;C12N15/11;C12Q1/68 |
主分类号 |
C12N15/113 |
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