LACIDIPINE CONTAINING GRANULES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: A pharmaceutical composition containing lacidipine-containing granule is provided to ensure high elution rate and solubility and to enhance accumulated elution rate. CONSTITUTION: A lacidipine-containing granule is formed by coating lacidipine, surfactant, and polyvinyl pyrrolidone on the surface of water-soluble saccharide particle. The content of surfactant is 5-200 weight parts based on 100 weight parts of lacidipine. The content of polyvinylpyrrolidone is 50-1500 weight parts based on 100 weight parts of lacidipine. The coating is performed by spray-coating on the water-soluble saccharide.