发明名称 |
TREATMENT OF MAJOR ADVERSE CARDIAC EVENTS AND ACUTE CORONARY SYNDROME USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITOR OR SPLA2 INHIBITOR COMBINATION THERAPIES |
摘要 |
<p>Administration of sPLA2 inhibitors in combination with statins has been found to reduce major adverse cardiac events (MACEs), inflammatory biomarker levels, and LDL-C levels in subjects who have recently experienced an index ACS event to a significantly greater degree than statins alone. These results were unexpected given previous results showing that statins alone are insufficient to satisfactorily reduce MACEs and inflammation in this high-risk population. Therefore, provided herein are methods of treating MACEs, treating ACS, inhibiting inflammation, and lowering cholesterol levels in a subject who has previously experienced an ACS event by administering one or more sPLA2 inhibitors alone or in combination with one or more statins.</p> |
申请公布号 |
WO2010071854(A1) |
申请公布日期 |
2010.06.24 |
申请号 |
WO2009US68869 |
申请日期 |
2009.12.18 |
申请人 |
ANTHERA PHARMACEUTICALS, INC.;HISLOP, COLIN;TRIAS, JOAQUIM;ODINK, DEBRA;TRUEX, PAUL |
发明人 |
HISLOP, COLIN;TRIAS, JOAQUIM;ODINK, DEBRA;TRUEX, PAUL |
分类号 |
A01N43/38;A61K31/40 |
主分类号 |
A01N43/38 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|