| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention refers to acid addition salts of 5-amonilevulinic acid ester (5-ALA ester) with acid in the form of solphonic acid derivative selected out of C1-C4-alkanesulphonic acid, benzolsulpnonic acid substituted with C1-4-alkyl, 2-hydroxy-ethanesulphonic acid and (+)-camphor-10-sulphonic acid, or nitric acid, where 5-ALA ester is a compound of the formula R2Çè2N-CH2COCH2-CH2CO-OR1 (R1 is unramified or ramified C1-6-alkyl group which can be possibly interrupted with one or two -O- groups and possibly substituted with phenyl, which in turn can be substituted with unramified or ramified C1-6-alkyl group; R2 is hydrogen atom). Also invention refers to methods of obtainment of the claimed salts, their application, pharmaceutical composition and methods of photochemotherapeutical treatment and in vitro diagnostics. ^ EFFECT: application of claimed salts as photosensitising agents in photodynamic therapy or diagnostics. ^ 23 cl, 2 tbl, 10 dwg, 42 ex |
