发明名称 |
VACCINES AGAINST INFLUENZA VIRUS |
摘要 |
Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
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申请公布号 |
US2010150954(A1) |
申请公布日期 |
2010.06.17 |
申请号 |
US20090541804 |
申请日期 |
2009.08.14 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
MILLER MARK A.;SCHNEERSON RACHEL;KUBLER-KIELB JOANNA;ROBBINS JOHN B.;BIESOVA ZUZANA;KEITH JERRY |
分类号 |
A61K39/385;A61P31/16;C07K17/06 |
主分类号 |
A61K39/385 |
代理机构 |
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地址 |
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