Insulin analogues wherein the B25 amino acid residue is His or Asn with the proviso that if the B25 amino acid residue is His, then the B27 amino acid residue is Asp or GIu and the A14 amino acid residue is different from GIu, have liver preferential actions.
申请公布号
WO2010066636(A1)
申请公布日期
2010.06.17
申请号
WO2009EP66335
申请日期
2009.12.03
申请人
NOVO NORDISK A/S;STIDSEN, CARSTEN, ENGGAARD;GLENDORF, TINE;KJELDSEN, THOMAS, BOERGLUM