发明名称 |
Non-pegylated long-circulating liposomes |
摘要 |
<p>Long circulating non-pegylated liposomes are formed by hydrating lipids formed from a lipid solution comprising a phospholipid, sterol and a solvent with 10 to 35 ml aqueous hydration medium per mmole of phospholipid. The hydration can be carried out before or after solvent removal. Preferably, the hydration medium comprises ammonium sulphate and sucrose and extraliposomal ammonium sulphate is removed using a sucrose-histidine buffer solution. The liposomes can be loaded with a therapeutic or diagnostic agent, especially doxorubicin hydrochloride.</p> |
申请公布号 |
AU2003303368(B2) |
申请公布日期 |
2010.06.17 |
申请号 |
AU20030303368 |
申请日期 |
2003.12.31 |
申请人 |
ZYDUS BSV RESEARCH AND DEVELOPMENT PRIVATE LIMITED |
发明人 |
SANGEETA HANURMESH RIVANKAR;SRIKANTH ANNAPPA PAI;GAUTAM VINOD DAFTARY |
分类号 |
A61K9/127;A61K9/133;A61K31/704;A61K47/24;A61P35/00;B01J13/02 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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