发明名称 |
PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT GASGEFÜLLTEN MIKROKAPSELN FÜR ULTRASCHALL-VERMITTELTE ABGABE |
摘要 |
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein. |
申请公布号 |
AT470438(T) |
申请公布日期 |
2010.06.15 |
申请号 |
AT20060725707T |
申请日期 |
2006.04.11 |
申请人 |
BRACCO RESEARCH S.A. |
发明人 |
BETTINGER, THIERRY;YAN, FENG;MEHIER-HUMBERT, SOPHIE;FRINKING, PETER |
分类号 |
A61K9/52 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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