USE OF PHENOL-SOLUBLE MODULINS FOR VACCINE DEVELOPMENT

摘要

The invention relates to methods for enhancing the immunogenicity of an antigenic peptide by means of the covalent coupling thereof to a modulin-derived peptide (PSM, phenol-soluble modulin). In particular, bonding of the PSMa, PSM? and PSMd peptides to an antigen (originating from a pathogen or from a tumour-associated protein) enhances the capacity of the antigen to trigger an in vivo immune response. Thus, the PSMa, PSM? and PSMd peptides bound to said antigen can be used in vaccine development to prevent or to treat infectious diseases or cancer.