发明名称 |
STATISTICAL VALIDATION OF CANDIATE GENES |
摘要 |
Provided herein are methods for evaluating associations between candidate markers and a trait of interest in a plant population. In various embodiments, the plant population is a breeding population, particularly early stage breeding populations. The methods include obtaining a genotypic value for candidate markers and correlating the marker with the trait. Various association models can be used to evaluate the association, and include statistical methods relevant to the structure of plant breeding populations. Population structure may be accounted for in the association models by using Principle Component Analysis. Further provided is a novel statistical approach for association mapping in early stage breeding materials using a transmission disequilibrium based methodology. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, for constructing genetic linkage maps, to identify genes contributing to a trait of interest, and for generating transgenic plants having a desired trait.
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申请公布号 |
CA2745257(A1) |
申请公布日期 |
2010.06.10 |
申请号 |
CA20092745257 |
申请日期 |
2009.12.04 |
申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
KISHORE, VENKATA KRISHNA;WANG, DAOLONG;GUTIERREZ ROJAS, LIBARDO ANDRES;MARTIN, NICOLAS FEDERICO |
分类号 |
G06F19/00 |
主分类号 |
G06F19/00 |
代理机构 |
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