| 发明名称 |
N-CARBAMOYLMETHYL-4(R)-PHENYL-2-PYRROLIDINONE, METHOD OF ITS PREPARATION AND PHARMACEUTICAL USE |
| 摘要 |
<p>The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.</p> |
| 申请公布号 |
PT2013166(E) |
申请公布日期 |
2010.06.09 |
| 申请号 |
PT20070726915T |
申请日期 |
2007.03.15 |
| 申请人 |
AKCIJU SABIEDRIBA OLAINFARM |
发明人 |
IVARS KALVINSH;ALEKSANDRS CHERNOBROVIJS;GRIGORY VEINBERG;MAKSIM VORONA;LIGA ZVEJNIECE;LIGITA KARINA;MAIJA DAMBROVA |
| 分类号 |
C07D207/26;A61K31/4015;A61P21/02;A61P25/00;A61P25/24 |
主分类号 |
C07D207/26 |
| 代理机构 |
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代理人 |
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| 地址 |
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