发明名称 |
Substituted benzimidazoles and methods of their use |
摘要 |
New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
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申请公布号 |
US7732465(B2) |
申请公布日期 |
2010.06.08 |
申请号 |
US20080315779 |
申请日期 |
2008.12.05 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
AIKAWA MINA E.;AMIRI PAYMAN;DOVE JEFFREY H.;LEVINE BARRY HASKELL;MCBRIDE CHRISTOPHER;PICK TERESA E.;POON DANIEL J.;RAMURTHY SAVITHRI;RENHOWE PAUL A.;SHAFER CYNTHIA;STUART DARRIN;SUBRAMANIAN SHARADHA |
分类号 |
A61K31/4439 |
主分类号 |
A61K31/4439 |
代理机构 |
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