| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a contaminant-free and high-quality epinastine hydrochloride. SOLUTION: There is provided a method for producing 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride (epinastine hydrochloride) expressed by formula II which comprises purifying 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine expressed by formula I by recrystallization using an alcohol such as isopropanol as a solvent, and bringing the same to be a hydrochloride. COPYRIGHT: (C)2010,JPO&INPIT
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