发明名称 |
STABLE ANTIBODY COMPOSITIONS AND METHODS FOR STABILIZING SAME |
摘要 |
<p>The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.</p> |
申请公布号 |
CA2742791(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
CA20092742791 |
申请日期 |
2009.11.24 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
CORREIA, IVAN R.;RADZIEJEWSKI, CZESLAW H.;FRAUNHOFER, WOLFGANG;WARNE, NICHOLAS W.;KANTOR, ANGELA |
分类号 |
A61K47/16;A61K39/395;G01N33/50 |
主分类号 |
A61K47/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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