QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS

摘要

A series of quinoline derivatives, substituted at the 2-position by a heteroaryl group attached via an alkylene chain optionally linked to a heteroatom, and at the 3-position by a carbocyclic or heterocylic ring, being selective inhibitors of PD kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.