摘要 |
<p>The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompability complexes (MHC), for detecting antigen responsive cells in a sample, preferably a single sample, such as a blood sample. The present method allows high-throughput analysis of specific antigen responsive cells, such as T- and B-cells, thereby providing, for example, high-throughput methods for monitoring of diseases or conditions and the development of immunotherapeutics, vaccines, or the identification epitopes or immunogenic amino acid sequences.</p> |
申请人 |
STICHTING SANQUIN BLOEDVOORZIENING;STICHTING HET NEDERLANDS KANKER INSTITUUT;HADRUP, SINE, REKER;BAKKER, ARNOLD, HENDRIK;SHU, CHENG YI, JENNY;SCHUMACHER, ANTONIUS, NICOLAAS, MARIA |
发明人 |
HADRUP, SINE, REKER;BAKKER, ARNOLD, HENDRIK;SHU, CHENG YI, JENNY;SCHUMACHER, ANTONIUS, NICOLAAS, MARIA |