发明名称 |
RATE MODULATED DELIVERY OF DRUGS FROM A COMPOSITE DELIVERY SYSTEM |
摘要 |
This invention relates to a pharmaceutical dosage form for the delivery of at least one active pharmaceutical ingredient (API) or the pharmaceutically active salts and isomers thereof, to a desired absorption location of the human or animal body, preferably the gastrointestinal tract, in a predetermined rate-modulated manner. The dosage form is orally ingestible and is in the form of a multi-layered tablet preferably three layers and each layer includes an API or capsule containing a multiplicity of multi-layered granules. Each layer contains one or more APIs mixed or blended with at least one and preferably a matrix of polymers and, where appropriate, excipients, which, in use, inhibit release of an API in a region of the gastrointestinal tract other than the desired absorption location and, thus, facilitate release of the API in a rate controlled manner when in the desired absorption location. Methods of manufacturing said dosage form are futher disclosed. |
申请公布号 |
WO2010020856(A3) |
申请公布日期 |
2010.06.03 |
申请号 |
WO2009IB06574 |
申请日期 |
2009.08.18 |
申请人 |
ADCOCK INGRAM HEALTHCARE (PTY) LIMITED;HIBBS, KIM, MELLSSA;PILLAY, VINESS;CHOONARA, YAHYA, ESSOP;PARSONS, BRADLEY, RYAN |
发明人 |
HIBBS, KIM, MELLSSA;PILLAY, VINESS;CHOONARA, YAHYA, ESSOP;PARSONS, BRADLEY, RYAN |
分类号 |
A61K9/20;A61K31/135;A61K31/167;A61K31/196 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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