发明名称 |
GIPs, a Family of Polypeptides with Transcription Factor Activity that Interact with Goodpasture Antigen Binding Protein |
摘要 |
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors. The invention further provides methods for detecting the GIP90/130 polypeptides or nucleic acid sequences, methods for inhibiting interactions between GPBP and GIP90/130 polypeptides, between pol k76 and GIP90/130 polypeptides or aggregation of GIP90/130 polypeptides, and methods for treating patients with autoimmune disorders or cancer.
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申请公布号 |
US2010136014(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20090571363 |
申请日期 |
2009.09.30 |
申请人 |
SAUS JUAN;REVERT-ROS FRANCISCO |
发明人 |
SAUS JUAN;REVERT-ROS FRANCISCO |
分类号 |
A61K39/395;G01N33/53;A61K38/00;A61K38/08;A61P35/00;A61P37/06;C07H21/04;C07K7/06;C07K7/08;C07K14/435;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/00;C12N5/02;C12N5/06;C12N5/10;C12N15/09;C12N15/12;C12N15/63;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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