发明名称 |
Agents and Methods Related to Reducing Resistance To Apoptosis-Inducing Death Receptor Agonists |
摘要 |
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins. |
申请公布号 |
US2010135951(A1) |
申请公布日期 |
2010.06.03 |
申请号 |
US20070814551 |
申请日期 |
2007.02.09 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
ZHOU TONG;KIMBERLY ROBERT P. |
分类号 |
A61K38/19;A61K38/00;A61K39/395;C07H21/02;C07K2/00;C12N5/071;C12N5/10;C12N15/74;G01N33/567 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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