VACCINE COMPOSITION FOR PREVENTION OR TREATMENT OF PNEUMOCOCCAL INFECTIONS COMPRISING VNCR/S OPERON-DISABLED STREPTOCOCCUS PNEUMONIA MUTANT STRAIN OR PEP27 PEPTIDE

摘要

Disclosed is an attenuated, Streptococcus pneumoniae strain in which a pep27 is so mutated as not to be expressed even upon infection into human lung cells. A vaccine composition comprising the attenuated, live Streptococcus pneumoniae strain and a peptide vaccine composition comprising a pneumococcal pep27 peptide are provided for the prevention and treatment of pneumococcal infections. Also, a method for diagnosing pneumococcal infections and a diagnostic kit therefore are provided. The method features detecting a pneumococcal pep27 gene or pep27 peptide.