| 摘要 |
1:8-Diamino-p-menthane is prepared by a process involving reaction of a terpenoid compound, hydrogen cyanide and sulphuric acid in the presence of water, the terpenoid compound being limonene, terpin hydrate, a - or b -terpineol or a -pinene, which process comprises heating the terpenoid compound to a temperature of about 40 DEG to 60 DEG C., adding aqueous solutions of hydrogen cyanide and sulphuric acid at such a rate that the temperature of the reaction mixture is maintained at about 40 DEG to 60 DEG C., hydrogen cyanide being added in an amount from two or three moles per mole of terpenoid compound, sulphuric acid being added in an amount from 1.5 to 5.0 moles per mole of terpenoid compound and water being added in amount equal to about 0.1 to about five times the weight of the sulphuric acid; continuing heating the mixture at about 40 DEG to 60 DEG C. for about two to four hours whereby the diformamido derivative of the respective terpene is formed; thereafter adding to the reaction mixture water in an amount of about one to nine times the weight of sulphuric acid originally present; steam distilling the diluted mixture until organic matter is no longer steam distilled, neutralising the mixture with a base strong enough to form the free diamine (e.g. sodium, potassium or calcium hydroxides) whereby a water-insoluble organic layer is formed comprising essentially purified 1:8-diamino-p-menthane and separating this layer. The process is described further in examples. Specification 681,688 is referred to.
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