发明名称 |
Potent, selective and non toxic c-kit inhibitors |
摘要 |
The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more particularly compounds selected to be potent inhibitors of constitutively activated c-kit, while being unable to inhibit other activation pathways as for example the pathways leading to death of IL-3 dependent cells cultured in presence of IL-3.
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申请公布号 |
US7727731(B2) |
申请公布日期 |
2010.06.01 |
申请号 |
US20030482037 |
申请日期 |
2003.12.29 |
申请人 |
AB SCIENCE |
发明人 |
MOUSSY ALAIN;DUBREUIL PATRICE;HERMINE OLIVIER |
分类号 |
C12Q1/02;G01N33/48;A61K31/00;A61K31/015;A61K31/095;A61K31/40;A61K31/403;A61K31/404;A61K31/415;A61K31/4709;A61K31/498;A61K31/505;A61K31/506;A61K31/517;A61K31/519;A61K45/06;C12N15/09;C12Q1/18;C12Q1/48;G01N33/15;G01N33/50;G01N33/566;G01N33/573 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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