发明名称 CRYSTALLINE MICROPOWDER PARTICLES
摘要 Crystalline particles of N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6&beta-yl)-phthalimide or a pharmaceutically acceptable salt thereof. Theses crystalline particles have a particle diameter distribution, wherein the particle diameter (D50) at the point attaining a cumulative frequency of 50% in volume distribution counted from the smallest particle diameter ranges from 1 to 30 μm while the particle diameter (D90) at the point attaining a cumulative frequency of 90% in volume distribution counted from the smallest particle diameter is not more than 90 μm, and a degree of crystallization of 80% or more. These crystalline particles make it possible to improve the biological availability of the active ingredient while ensuring the storage stability of the above-described compound.
申请公布号 KR20100056424(A) 申请公布日期 2010.05.27
申请号 KR20097024379 申请日期 2008.05.20
申请人 TORAY INDUSTRIES, INC. 发明人 AKIMOTO MASAHIRO;KOMAGATA TOSHIKAZU;SHIRAKI MOTOHIRO;ANDO AKIHIRO
分类号 C07D498/08;A61K31/485;A61P13/10;A61P25/04 主分类号 C07D498/08
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