2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF INFLAMMATORY CYTOKINES

摘要

1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines of formula (I) in which Y is oxygen or H2, one of R1 and R2 is halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl, the other of R1 and R2 is independently hydrogen, halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl and; R3 is hydrogen, alkyl, or benzyl, and the method of reducing levels of tumor necrosis factor .alpha. and other inflammatory cytokines in a mammal through the administration of such derivatives, and pharmaceutical compositions containing such derivatives.