发明名称 |
METHOD FOR FORMING ALLYLIC ALCOHOLS |
摘要 |
A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an aldehyde or a hemiacetal. The reaction mixture includes a ruthenium catalyst, carbon monoxide at a level of at least 1 equivalent relative to the substrate, and water at a level of at least 1 equivalent relative to the substrate, and an amine at a level of from 0 to 0.5 equivalent relative to the substrate. The reaction mixture may also include a halide, and the equivalents of the amine may be similar to those of the halide. The reacting includes maintaining the reaction mixture at a temperature of at least 40°C. The method may be catalytic in metal, environmentally benign, amenable to large-scale applications, and applicable to a wide range of substrates. |
申请公布号 |
WO2010025366(A3) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009US55363 |
申请日期 |
2009.08.28 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;DENMARK, SCOTT E.;MILICEVIC, SELENA;NGUYEN, SON T. |
发明人 |
DENMARK, SCOTT E.;MILICEVIC, SELENA;NGUYEN, SON T. |
分类号 |
C07C29/14;B01J31/28;C07C33/20;C07C215/30;C07D307/36 |
主分类号 |
C07C29/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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