SYNTHESIS OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]- PIPERAZINYL)DIBENZO[B,F][1,4]THIAZEPINE AND ITS FUMARATE SALT

摘要

This invention broadly relates to a method for synthesizing ll-(4-[2-(2- hydroxyethoxy)ethyl]-piperazinyl)-dibenzo[b,f][l,4]thiazepine hemifumarate salt (Quetiapine hemifumarate) and the intermediate 11- piperazinyldibenzo[b,f][l,4]thiazepine dihydrochloride using phosphorous oxychloride in presence of non-aromatic solvent and condensing with piperazine.