发明名称 |
PHOTOREACTIVE COMPOUND SPECIFICALLY BINDING TO CALCIUM BINDING PROTEINS |
摘要 |
The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders. |
申请公布号 |
EP1722818(B1) |
申请公布日期 |
2010.05.19 |
申请号 |
EP20050703240 |
申请日期 |
2005.02.17 |
申请人 |
SHOSHAN-BARMATZ, VARDA;ISRAELSON, ADRIAN |
发明人 |
SHOSHAN-BARMATZ, VARDA;ISRAELSON, ADRIAN |
分类号 |
A61K47/00;A61K;A61K41/00;A61K51/02;C07H19/00;C07K14/47;C12N11/14 |
主分类号 |
A61K47/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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