METHOD OF USING TETRACYCLINE COMPOUNDS TO ENHANCE INTERLEUKIN-10 PRODUCTION
摘要
The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF .alpha. production.
申请公布号
CA2339667(C)
申请公布日期
2010.05.18
申请号
CA19992339667
申请日期
1999.09.10
申请人
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;UNIVERSITY OF ROCHESTER
发明人
GOLUB, LORNE M.;RITCHLIN, CHRISTOPHER T.;GREENWALD, ROBERT A.;HAAS-SMITH, SALLY;MOAK, SUSAN A.;LEE, HSI-MING