A non-auxotrophic selection marker located in a gene cluster encoding a metabolite for an organism, such as a fungus, lacking said marker is provided. The selection marker gene can be used to detect and confirm the introduction of foreign genes without the use of exogenous drug-resistant genes to facilitate transformant selection. The selection marker gene can be applied to detect the presence of fungal infection and predict the likelihood of the development of disease or allergic response at an early stage so that medical intervention may be sought.
申请公布号
WO2010032230(A9)
申请公布日期
2010.05.14
申请号
WO2008IE00091
申请日期
2008.09.22
申请人
NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH;CARBERRY, STEPHEN;DOYLE, JOHN, MARTIN;HAAS, HUBERTUS;KAVANAGH, KEVIN;SCHRETTL, MARKUS
发明人
CARBERRY, STEPHEN;DOYLE, JOHN, MARTIN;HAAS, HUBERTUS;KAVANAGH, KEVIN;SCHRETTL, MARKUS