Composition useful e.g. for treating inflammation and pain, comprises diclofenac, menthol, thickening agent and optionally auxiliary materials in a mixture of water and lower alkanol

摘要

#CMT# #/CMT# Composition comprises diclofenac or its salt (0.5-2 wt.%), menthol (0.2-1 wt.%), thickening agent (0.4 wt.%) and optionally other auxiliary materials in a mixture of water and lower alkanol. #CMT# : #/CMT# An independent claim is also included for an aerosol spray comprising the composition. #CMT#ACTIVITY : #/CMT# Antiinflammatory; Analgesic; Antiarthritic; Antigout; Antirheumatic. #CMT#MECHANISM OF ACTION : #/CMT# Cyclooxygenase inhibitor. #CMT#USE : #/CMT# The composition is useful for treating inflammation and pain, preferably arthritis, gout and rheumatism. No biological data given. #CMT#ADVANTAGE : #/CMT# The composition: is applied as a spray, thus rapid absorption of the active ingredients is achieved; exhibits good storage stability, thus preventing turbidity of the solution and crystallization of the active ingredient even after prolonged storage; has comparatively low concentration of the diclofenac, thus preventing discoloration of the skin or clothes if accidentally sprayed; exhibits no harmful side effects with excessive use, thus can be applied without a doctor's prescription and supervision. #CMT#PHARMACEUTICALS : #/CMT# Preferred Composition: The composition further comprises adipic acid diisopropyl ester and lactic acid. Preferred Components: The composition comprises sodium (preferred), potassium or ammonium salt of diclofenac. The amount of sodium salt of diclofenac is 1 wt.%. The weight ratio of diclofenac to menthol is 3:1-1:2, preferably 2:1. The menthol is levomenthol. The lower alkanol is isopropanol. The thickening agent is hydroxypropyl cellulose, hydroxypropyl methylcellulose or xanthan gum. #CMT#ADMINISTRATION : #/CMT# Administration of the composition is topical in the form of spray. #CMT#EXAMPLE : #/CMT# Typical composition comprised of: diclofenac sodium salt (1 wt.%); adipic acid diisopropyl ester (3 wt.%); lactic acid 90% (0.04 wt.%); sodium bisulfite (0.05 wt.%); isopropanol (40 wt.%); levomenthol (12.50 wt.%); hydroxypropyl cellulose (0.02 wt.%) and water (55.39 wt.%).