发明名称 |
IMPROVED ANTI-CD19 ANTIBODIES |
摘要 |
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases. In more particular embodiments, the humanized anti-CD19 antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. In a particularly preferred embodiment, the substitutions comprise a Ser91Phe substitution in the hA19 VH sequence. |
申请公布号 |
WO2010053716(A1) |
申请公布日期 |
2010.05.14 |
申请号 |
WO2009US61666 |
申请日期 |
2009.10.22 |
申请人 |
IMMUNOMEDICS, INC.;HANSEN, HANS J.;QU, ZHENGXING;GOLDENBERG, DAVID M. |
发明人 |
HANSEN, HANS J.;QU, ZHENGXING;GOLDENBERG, DAVID M. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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