ANTI-MUC1 ANTIBODY

摘要

Disclosed is an antibody which does not bind to a normal cell and is specific to a cancer cell.  It is found that, contrary to expectation, an antibody produced by immunizing an animal by using 2,3ST glycopeptide as an antigen can recognize a cancer-specific sugar chain significantly and specifically, and can also recognize and kill a cancer cell capable of expressing MUC1 that has such a cancer-cell-specific sugar chain.  Thus, specifically disclosed are: an antibody of which the specificity to a cancer-related structure of MUC1 is higher by 100 times or more than the specificity to a normal-tissue-related structure of MUC1; an antigen-binding fragment or MUC1-binding molecule of the antibody; and others.