发明名称 |
OPTIMIZED METHODS FOR DIFFERENTIATION OF CELLS INTO CELLS WITH HEPATOCYTE AND HEPATOCYTE PROGENITOR PHENOTYPES, CELLS PRODUCED BY THE METHODS, AND METHODS FOR USING THE CELLS |
摘要 |
<p>The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.</p> |
申请公布号 |
WO2010049752(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2008IB03868 |
申请日期 |
2008.10.31 |
申请人 |
KATHOLIEKE UNIVERSITEIT LEUVEN;PAUWELYN, KAREN;VERFAILLIE, CATHERINE |
发明人 |
PAUWELYN, KAREN;VERFAILLIE, CATHERINE |
分类号 |
C12N5/071 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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