发明名称 |
ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION |
摘要 |
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R', R", W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
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申请公布号 |
CA2741433(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
CA20092741433 |
申请日期 |
2009.09.23 |
申请人 |
CONGENIA S.R.L. |
发明人 |
FANCELLI, DANIELE;VARASI, MARIO;PLYTE, SIMON;BALLARINI, MARCO;CAPPA, ANNA;CARENZI, GIACOMO;MINUCCI, SAVERIO;PAIN, GILLES;VILLA, MANUELA |
分类号 |
C07C235/38;C07C235/36;C07C323/41;C07D209/08;C07D211/22;C07D211/46;C07D213/30;C07D213/32;C07D213/38;C07D213/68;C07D213/75;C07D231/12;C07D231/56;C07D233/60;C07D295/135 |
主分类号 |
C07C235/38 |
代理机构 |
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地址 |
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