Antimicrobial oxazolidinone derivatives

摘要

A compound of the formula:
or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring A is
(A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms;
(A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or
(A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom, wherein said monocyclic hetero ring is optionally substituted, and said monocyclic hetero ring is optionally condensed with another ring,
X 1 is a single bond, or a hetero atom-containing group selected from the group consisting of -O-, -S-, -NR 2 -, -CO-, -CS-, -CONR 3 -, -NR 4 CO-, -SO 2 NR 5 -, and -NR 6 SO 2 -, wherein R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said hetero atom-containing group;
Ring B is optionally substituted carbocycle or optionally substituted heterocycle;
R 1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent.