| 发明名称 |
N-OXIDES AND DERIVATIVES OF MELPHALAN FOR TREATING DISEASED STATES ASSOCIATED WITH HYPOXIA INDUCIBLE FACTOR |
| 摘要 |
This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF: formula (I) wherein R is an alkyl, aryl, arakyl or derivatives thereof such as CH3OCH2CH2- , CH3 CH2OCH2CH2- , C6H5OCH2CH2- , C6H5CH2- , CH3 (CH2)3OCH2CH2Cl; or any one of the formula (II), formula (III) and formula (IV).
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| 申请公布号 |
CA2504496(C) |
申请公布日期 |
2010.05.04 |
| 申请号 |
CA20032504496 |
申请日期 |
2003.11.03 |
| 申请人 |
PROLX PHARMACEUTICALS CORPORATION;ARIZONA BOARD OF REGENTS, ACTING ON BEHALF OF THEUNIVERSITY OF ARIZONA |
发明人 |
KIRKPATRICK, LYNN;POWIS, GARTH;WELSH, SARAH J. |
| 分类号 |
C07C229/28;A61K31/195;A61K31/66;C07F9/547;C07F9/6584 |
主分类号 |
C07C229/28 |
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