High affinity HIV T cell receptors

摘要

Provided is a T-cell receptor (TCR) having the property of binding to SLYNTVATLHLA- A*0201 and comprising at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain wherein (i) the TCR a chain variable domain has a specified sequence except that at least one complementarity determining region thereof is/are mutated and/or the TCR alpha chain variable domain has a specified sequence except that at least one complementarity determining region thereof is/are mutated; and (ii) the TCR has a KD for the said SLYNTVATL-HLA-A*0201 complex of less than or equal to 1 micromole and/or has an off-rate (koff) for the SLYNTVATL-HLA-A*0201 complex of 1 x 10-3s-1 or slower. Further provided are corresponding pharmaceutical compositions.