| 主权项 |
1. A compound of the formula (I): whereinZ is selected from the group consisting of 2-thiazolyl, 4-thiazolyl, 1-thia-3,4-diazolyl, and 1-thia-2,4-diazolyl,
in which each may be optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, and di[(C1-C4)alkyl]amino(C1-C4)alkyl;
Y1, Y2, Y3 and Y4 are each independently CH or CR1;each R1 is independently selected from the group consisting of halo, cyano, amino, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)H, —C(O)(C1-C4)alkyl, and —C(O)N(R2)2;each R2 is independently hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, or (C3-C6)cycloalkyl; or, where a nitrogen is substituted with two R2 groups, each independently selected from (C1-C4)alkyl, halo(C1-C4)alkyl, or hydroxy(C1-C4)alkyl, they may be taken together with the N atom to which they are attached to form a 4- to 6-membered ring which, when so formed, may therefore optionally be substituted with hydrogen, alkyl, halo, hydroxy, hydroxyalkyl or haloalkyl;B is phenyl which may be optionally substituted with one or more substituents selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, cyano(C1-C4)alkyl, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, S(O)2N(R2)2, (C3-C8)cycloalkyl, and (C3-C8)cycloalkyl(C1-C4)alkyl;X is absent; C is selected from the group consisting of pyrazolyl; pyridinyl; pyridazinyl; and, pyrimidinyl,
in which each may be optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, N(R2)2, (R2)2N(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, S(O)2N(R2)2, (C3-C8)cycloalkyl(C1-C4)alkyl, (C3-C8)cycloalkoxy, (C3-C8)cycloalkylamino, (C3-C8)cycloalkylamino(C1-C4)alkyl, (C3-C8)cycloalkyl(C1-C4)alkylamino, (C3-C8)cycloalkyl(C1-C4)alkylamino(C1-C4)alkyl, (C3-C8)cycloalkyl(C1-C4)alkoxy;or a tautomer thereof, or a pharmaceutically acceptable salt or solvate of the compound of formula (I), or its tautomer. |
