发明名称 |
Rapid dissolution formulation of a calcium receptor-active compound |
摘要 |
Disclosed is a pharmaceutical composition comprising a) from about 10% to about 40% by weight of cinacalcet HCl; b) from 40% to about 75% by weight of microcrystalline cellulose; c) from about 1% to about 5% by weight of povidone; d) from about 5% to about 35% by weight of starch; e) from about 1% to about 10% by weight of crospovidone; f) from about 0.05% to about 1.5% by weight of colloidal silicon dioxide; and g) from about 0.05% to about 1.5% by weight of magnesium stearate; wherein the percentage by weight is relative to the total weight of the composition. Also disclosed is the use of the above composition in the manufacture of a medicament for the treatment of hyperparathyroidism, hyperphosphonia, hypercalcemia, and elevated calcium phosphorus product. |
申请公布号 |
NZ545498(A) |
申请公布日期 |
2010.04.30 |
申请号 |
NZ20040545498 |
申请日期 |
2004.09.10 |
申请人 |
AMGEN INC. |
发明人 |
ALVAREZ, FRANCISCO J;LAWRENCE, GLEN GARY;LIN, HUNG-REN H;JU, TZUCHI R |
分类号 |
A61K31/00;A61K9/20;A61K9/28;A61K31/135;A61K31/137;A61P5/18;C07C211/26 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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