DELIVERY OF NUCLEIC ACID-LIKE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a microparticulate complex, and to provide a method for producing the complex.

SOLUTION: A microparticulate complex that comprises a particle-forming component is complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water. The method for producing the microparticulate complex comprises: (a) a step for combining a particle-forming component ("PFC") and a nucleic acid-like component ("NAC") in a monophasic composition comprising water and a water-miscible organic solvent to form a mixture (wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system); and (b) a step for reducing the amount of the organic solvent in the mixture. The method is effective for formation of the microparticulate complex of the NAC and the PFC.

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