MACROPOROUS POLYMERIC CROSSLINKED MATERIALS, METHOD FOR MANUFACTURE THEREOF AND USE

摘要

Disclosed is a method for generating macroporous polymeric crosslinked materials and the materials obtained therewith. The method uses beads of reversible hydrogels or selected core-shell beads as pore forming materials which are introduced as solid beads into a liquid of polymerisable monomers, for example via a drop-on-demand technique. After the polymerisation of the monomers the solid beads are liquefied and the pore-forming material is removed from the polymer matrix. This technique allows formation of macropores with uniform diameter and with a high amount of macropores being in fluid communication with each other. The macroporous polymeric crosslinked materials, preferably in the form of hydrogels, can be used as substrates in tissue-engineering.