发明名称 |
PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME |
摘要 |
The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I); and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific &bgr;-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.
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申请公布号 |
US2010105922(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
US20090648022 |
申请日期 |
2009.12.28 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
KAWAKAMI JUN-ICHI;NAKAMOTO KOJI;NUWA SHIGERU;HANDA SYOJI;MIKI SHOKYO |
分类号 |
C07D233/64;A61K31/4164;A61K31/4188;A61P13/08;A61P15/00;A61P17/14;A61P35/00;A61P43/00;C07C27/04;C07D213/55;C07D215/12;C07D233/54;C07D307/16;C07D307/33;C07D487/04;C07F3/06 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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