发明名称 US CIP-COMPOSITIONS AND METHODS FOR MODULATING RESPONSES MEDIATED OR ASSOCIATED WITH BTLA ACTIVITY
摘要 Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation.
申请公布号 US2010104559(A1) 申请公布日期 2010.04.29
申请号 US20090482426 申请日期 2009.06.10
申请人 WARE CARL F;TREZ CARL DE;CROFT MICHAEL;CHEUNG TIMOTHY C;HUMPHREYS IAN R;PORTER KAREN G;BENEDICT CHRISTOPHER A;KRONENBERG MITCHELL;STEINBERG MARCOS W 发明人 WARE CARL F.;TREZ CARL DE;CROFT MICHAEL;CHEUNG TIMOTHY C.;HUMPHREYS IAN R.;PORTER KAREN G.;BENEDICT CHRISTOPHER A.;KRONENBERG MITCHELL;STEINBERG MARCOS W.
分类号 A61K39/395;A61K38/00;A61P29/00;A61P35/00;C12N5/00 主分类号 A61K39/395
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