The current invention comprises a method for the purification of mono-PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
申请公布号
WO2009010270(A8)
申请公布日期
2010.04.29
申请号
WO2008EP05767
申请日期
2008.07.15
申请人
F.HOFFMANN-LA ROCHE AG;BURG, JOSEF;REICHERT, KLAUS;SCHROTH, AXEL;SCHURIG, HARTMUT;WESSNER, AXEL
发明人
BURG, JOSEF;REICHERT, KLAUS;SCHROTH, AXEL;SCHURIG, HARTMUT;WESSNER, AXEL
