VIRAL INACTIVATION DURING PURIFICATION OF ANTIBODIES
摘要
<p>Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.</p>
申请公布号
WO2010048192(A2)
申请公布日期
2010.04.29
申请号
WO2009US61338
申请日期
2009.10.20
申请人
ABBOTT LABORATORIES;HICKMAN, ROBERT, K.;CORREIA, IVAN, R.