USE OF E. COLI SURFACE ANTIGEN 3 SEQUENCES FOR THE EXPORT OF HETEROLOGOUS ANTIGENS
摘要
<p>The present invention provides an export signal system based on E. coli CS3 antigen for directing the secretion of foreign antigens from host cells. In particular, the invention describes genetic constructs encoding fusion proteins that contain a CS3 export signal fused to at least one heterologous amino acid sequence. Attenuated microorganisms expressing the fusion proteins and pharmaceutical compositions comprising such attenuated microorganisms are also disclosed.</p>
申请公布号
WO2010048322(A1)
申请公布日期
2010.04.29
申请号
WO2009US61528
申请日期
2009.10.21
申请人
EMERGENT PRODUCT DEVELOPMENT UNITED KINGDOM;EMERGENT BIOSOLUTIONS, INC.;TELFER, JONATHAN, LEWIS;REDFERN, MARK, RICHARD