The present invention relates to retroviral vector genomes and to vector systems comprising such genomes. In particular the present invention relates to a retroviral vector genome comprising two or more NOIs operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and optionally Aromatic Amino Acid Dopa Decarboxylase.
申请公布号
EP2180057(A1)
申请公布日期
2010.04.28
申请号
EP20090014156
申请日期
2001.10.05
申请人
OXFORD BIOMEDICA (UK) LIMITED
发明人
KINGSMAN, JOHN ALAN;MAZARAKIS, NICHOLAS D;MARTIN-RENDON, ENCA;AZZOUZ, MIMOUN;ROHLL, JONATHAN